![]() ![]() ![]() 5–8 However, there is a lack of sufficiently powered studies to assess the impact of AEDs on neurodevelopment in children of women exposed to these agents, especially for newer-generation drugs, thus highlighting the need for a systematic review. 5 6 No significant associations were found between neurodevelopment and exposure to other AEDs such as carbamazepine, lamotrigine or phenytoin. 2–4 Two systematic reviews examined the association between AED exposure and neurodevelopment in utero and reported that exposure to valproate was linked to significantly lower IQ scores and poorer overall neurodevelopmental outcomes in the children of women who used these medications. 1 AED use during pregnancy is associated with risks to the fetus as these drugs can cross the placenta or may be transferred to the infant through breast feeding and may be associated with adverse neurodevelopment outcomes. Antiepileptic drugs (AEDs) are used by pregnant women for various conditions, such as epilepsy, pain syndromes, psychiatric disorders and chronic migraine. ![]()
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